Treatment to prevent Alzheimers disease moves a step closer

A new drug designed to prevent the early stages of Alzheimer’s disease could enter clinical trials in a few years’  time, according to scientists.
Alzheimer’s disease begins when a protein called amyloid-β (Aβ) starts to clump together in senile plaques in the brain, damaging nerve cells and leading to memory loss and confusion.
Professor David Allsop and Dr Mark Taylor at Lancaster University have created a new drug that reduced the number of senile plaques by a third and more than doubled the number of new nerve cells in a particular region of the brain associated with memory.  It also markedly reduced the amount of brain inflammation and oxidative damage associated with the disease.
The drug was tested on transgenic mice containing two mutant human genes linked to inherited forms of Alzheimer’s, so that they would develop some of the changes associated with the illness. The drug is designed to cross the blood-brain barrier and prevent the Aβ molecules from sticking together to form plaques.
Professor Allsop, who led the research and was the first scientist to isolate senile plaques from human brain, said:  “When we got the test results back, we were highly encouraged. The amount of plaque in the brain had been reduced by a third and this could be improved if we gave a larger dose of the drug, because at this stage, we don’t know what the optimal dose is.”
The drug needs to be tested for safety before it can enter human trials. The aim would be to give the drug to people with mild symptoms of memory loss before they develop the illness.
“Many people who are mildly forgetful may go on to develop the disease because these senile plaques start forming years before any symptoms manifest themselves. The ultimate aim is to give the drug at that stage to stop any more damage to the brain, before it’s too late.”