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Scientists convert human stem cells into functional lung cells

RATE THIS! +34
Posted in Medicine on 8th Dec, 2013 12:53 AM by AlexMuller

Researchers at Columbia University Medical Center (CUMC) have transformed human stem cells into functional lung cells, paving the way for ultimately creating bioengineered lungs using the patient's own cells. Besides being able to generate lung tissue for transplants, these cells could also be used to study lung development and potentially find more advanced treatments for lung diseases.

 
While scientists have been able to successfully transform human stem cells into different types of cells such as nerve, retina and blood cells, creating working lung and airway cells proved to be a challenge.
 
"When an embryo develops, it first makes three layers of cells, or germ layers – ectoderm, which will become the skin and nervous system, mesoderm, which will become the heart, muscle, connective tissues, blood vessels, blood and kidney, and endoderm, which will become the intestine, liver, pancreas, stomach, esophagus, thyroid, thymus parathyroids, and lung," study leader Hans-Willem Snoeck tells Gizmag. "The endoderm forms last which is probably one reason why it is harder to specify from stem cells."
 
Studies that used the mouse embryo as a model couldn't demonstrate how the lung part of the endoderm formed. It wasn't possible for researchers to create lung cells until 2011, when Snoeck discovered a way to turn human embryonic stem cells into a particular type of cell, that were the precursors of lung cells.
 
"That was the first breakthrough that allowed this breakthrough," Snoeck explains. "We used what we knew from mouse development, and had to discover a few novel tricks."

Tags: healthlungstem cellsbioengineeringregenerative medicine

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Comments

Author: Guest
Posted: 2013-12-08
+2
Stem cells that will produce lung cells would clearly need more research and attention. Considering some serious lung diseases, they should have important application
3 Replies
Author: Guest
Posted: 2013-12-08
+1
This breakthrough will open the way to make "bioengineered lungs," that have little chance of rejection after transplantation Reply
Author: Guest
Posted: 2013-12-08
+0
This breakthrough is expected to advance the study of lung diseases whose cause has been hard to identify. Reply
Reply
Author: Guest
Posted: 2013-12-08
+0
There are at least seven broad types of lung and airway lining cells which scientists will now be able to create and some of these can repair damage and injuries. Reply
Author: Guest
Posted: 2013-12-08
+0
The approach is to reprogram adult cells (skin, blood …) to pluripotent stem cells similar to embryonic stem cells and convert them to lung cells- this is what they achieved in this work Reply
Author: Guest
Posted: 2013-12-08
+0
Transitory reprogramming could help in the natural regeneration of damaged tissue
2 Replies
Author: Guest
Posted: 2013-12-08
+0
Yes, we hope that one day it will be possible to replace damaged tissues and help the body regenerate itself, potentially curing or easing the suffering of those afflicted by disorders like heart disease, Alzheimers, Parkinsons, diabetes, spinal cord injury and cancer. Reply
Reply


 

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