New blood test to detect inherited heart conditions

A new blood test could help diagnose people with inherited heart conditions. Researchers found that by looking at a specific group of genes they were able to reliably detect underlying problems. It follows the death of Sir David Frost’s son Miles, who died suddenly from a condition thought to have been inherited
Inherited heart conditions are thought to affect more than 500,000 people in the UK. There are many different types which can affect the heart and circulatory system and they are passed down through families. They can affect people of any age and can be life-threatening
Genetic testing on family members can identify who carries the faulty gene and steps can be taken to reduce the risk of sudden death, such as surgery, medication or lifestyle changes. Previous genetic tests looked at a small number of genes and were only able to identify specific conditions, leading to higher costs and longer diagnosis time, a major barrier to rolling the test out across the NHS.
But researchers from Imperial College London and the MRC Clinical Sciences Centre say the new test, which looks at 147 genes, is quicker and more reliable. It has already been rolled out at the Royal Brompton and Harefield NHS Trust in Middlesex, with around 40 patients per month being successfully tested.
Dr James Ware, a consultant cardiologist specialising in inherited heart conditions, said: "Without a genetic test we often have to keep the whole family under regular surveillance for many years. This is hugely costly for both the families and the health system.
"By contrast, when a genetic test reveals the precise genetic abnormality causing the condition in one member of the family, it becomes simple to test other family members. Those who do not carry the faulty gene copy can be reassured and spared countless hospital visits."
The research has been funded by the British Heart Foundation and the findings published in the Journal of Cardiovascular Translational Research.