Mitochondria rejuvenation in mice gave memory and exercise performance boost.

Researchers took a naturally occurring mitochondrial transcription factor called TFAM, which initiates protein synthesis, and engineered it to cross into cells from the bloodstream and target the mitochondria.
Aged mice given modified TFAM showed improvements in memory and exercise performance compared with untreated mice. "It was like an 80-year-old recovering the function of a 30-year-old," says Rafal Smigrodzki, also at Gencia, who presented the results at the Strategies for Engineered Negligible Senescence conference in Cambridge this month.