Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.

 

Thomas Edison

Study links Alzheimer's disease with liver function and diet

RATE THIS! +9
Posted in Science on 25th Jul, 2018 03:49 AM by Alex Muller

Scientists have presented new research pointing to the liver as a potential culprit in the onset of Alzheimer's disease. Presented at the Alzheimer's Association International Conference, the research suggests that a compound produced in the liver can confer neurocognitive protections.

 

When the liver cannot effectively produce those compounds then cognitive deficits can result in the brain.

 

Molecules called plasmalogens were the primary focus of the new research. These are a class of lipids generated in the liver, and certain types have been found to be critical for effective synaptic function in the brain. The study set out to measure whether reduced levels of several specific types of plasmalogens corresponded with an increased risk of Alzheimer's or mild cognitive decline.

 

Over 1,500 human subjects were examined, split into three categories: those clinically diagnosed with Alzheimer's disease, those with clinically diagnosed mild cognitive impairment, or those healthy and cognitively normal. The results showed statistically significant differences in plasmalogen levels between all three groups with lower levels associated with higher rates of Alzheimer's or cognitive decline.

 

"This research shows that an age-related deficiency of plasmalogens could lead to an increased risk of Alzheimer's disease, because the liver cannot make enough of them," says Mitchel Kling, one of the researchers on the project.

 

The study isn't the first to implicate the liver as playing a role in the onset of Alzheimer's disease. A compelling study from 2011 found that one of the primary genes suspected in production of the pathogenic amyloid beta protein is mostly expressed in the liver. This study hypothesized that the proteins that are thought to be responsible for many cognitive deficits seen in Alzheimer's actually originate in the liver and then travel to the brain via the bloodstream.

 

Another study, similarly focused on the liver, found that an enzyme the organ produces generates fundamental neuroprotective effects, and when a person's liver isn't effectively producing it brain metabolism can suffer. This particular study was also examining a liver-generated lipid, much like the recent work.

 

Perhaps the most interesting implication suggested by this growing body of research is that dietary effects on the liver may play a role in the subsequent development of Alzheimer's and cognitive impairment. A recent study does back up this possible hypothesis, finding an association between non-alcoholic fatty liver disease and increased risk of Alzheimer's.

 

"[The new research] highlights a potential relationship between conditions such as obesity and diabetes and Alzheimer's – as the liver has to work harder to break down fatty acids over time," explains Kling. "This could lead to the eventual destruction of the peroxisomes that create plasmalogens which thus, increases the risk of Alzheimer's."

 

It is still early days for much of this research but it offers intriguing pathways suggesting scientists could do well by looking outside of the brain when trying to find new ways to approach and treat Alzheimer's disease.

 

"Moving forward, we're examining the connections between plasmalogens, other lipids, and cognition, in addition to gene expression in the liver and the brain," says Kling. "While we're in the early stages of discovering how the liver, lipids, and diet are related to Alzheimer's disease and neurodegeneration, it's been promising."


Tags: brainneurosciencehealthmedicineresearch

Read original article » Back to category

Comments



 

Recent headlines

  • Posted in Business on 2018-12-16 10:11:27
    Microsoft researchers beat Tencent and Intel in.....read more
    Posted in Hardware on 2018-12-14 18:46:46
    Starlink Means SpaceX Revenue Might Be Double NASA's Budget..read more
    Posted in Business on 2018-12-14 18:42:06
    IBM Has Ten Artificial Intelligence Achievements and.....read more
    Posted in Business on 2018-12-13 14:32:06
    China Mission in Lunar Orbit and May Race SpaceX for Next.....read more
    Posted in Business on 2018-12-13 14:20:51
    Apple will build a new $1 billion campus in Austin amid.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Even light drinking increases risk of death..read more
    Posted by AlexMuller
    Researchers have discovered how to slow aging..read more
    Posted by AlexMuller
    Human retinas grown in a dish explain how color vision develops..read more
    Posted by AlexMuller
    The smartphone app that can tell you’re depressed before you.....read more
    Posted by AlexMuller
    Neural networks don’t understand what optical illusions are..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me