Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

When seen through the lens of technology, few resources are truly scarce; they’re mainly inaccessible. 

 

Peter Diamandis

Motorized molecules that can drill into cancer cells

RATE THIS! +43
Posted in Science on 5th Sep, 2017 06:20 PM by Alex Muller
Dr Robert Pal at Durham University worked with researchers at Rice and North Carolina State universities in the USA to demonstrate in laboratory tests how rotors in single-molecule nanomachines can be activated by ultraviolet light to spin at two to three million rotations per second and open membranes in cells.
 
Test motors designed to target prostate cancer cells broke through their membranes from outside and killed them within one to three minutes of activation, said Dr Pal.
 
Dr Pal, of the Department of Chemistry and Biophysical Sciences Institute at Durham University, thinks that nanomachines could prove to be effective against a range of cancers including those that resist currently available treatments.
 
“We are moving towards realising our ambition to be able to use light-activated nanomachines to target cancer cells such as those in breast tumours and skin melanomas, including those that are resistant to existing chemotherapy,” said Dr Pal, a Royal Society Research Fellow.
 
“Once developed, this approach could provide a potential step change in non-invasive cancer treatment and greatly improve survival rates and patient welfare globally.”
 
The research used motors based on work by Nobel laureate Bernard Feringa, who won the prize for chemistry in 2016. The motor itself is a paddle-like chain of atoms that can be prompted to move in a single direction when supplied with energy.
 
Properly mounted as part of the cell-targeting molecule, the motor can be made to home in on specific cells and spin when activated by a light source.
 
The Rice laboratory created motor-bearing molecules in several sizes as well as peptide-carrying nanomachines designed to target and kill specific cells. North Carolina State University then tested the molecules on synthetic replicas of cell membranes.
 
Tests on live cells, including human prostate cancer cells, were conducted at Durham. These experiments showed that without an ultraviolet trigger, motors could locate specific cells of interest but stayed on the targeted cells’ surface and were unable to drill into the cells. When triggered, however, the motors rapidly drilled through the membranes.
 
Researchers expect the rotors may eventually be activated by other means, such as two-photon absorption, near-infrared light or radio frequencies, which would pave the way toward the establishment of novel, easy and cost-effective photodynamic therapy.
 
The research was supported by the National Science Foundation, North Carolina State University, the Royal Society and the Biophysical Sciences Institute at Durham University.

Tags: cancerhealthmedicineoncologychemistry

Read original article » Back to category

Comments

Author: Guest
Posted: 2017-09-06
+1
It is great to see promising data from multidisciplinary efforts. Further work that would improve activation of nano motors will hopefully bring this closer to cancer patients at the clinic
1 Replies
Author: Guest
Posted: 2017-09-06
+1
There are so many advances brought about by multidisciplinary approaches that are applicable to development of new medical treatments, some will no doubt prove to be effective Reply
Reply


 

Recent headlines

  • Posted in Science on 2017-11-24 09:26:38
    Spacex dedicated tanker versions of BFS for orbital.....read more
    Posted in Hardware on 2017-11-24 09:18:26
    China solar must increase 600% to displace coal, gas and.....read more
    Posted in Business on 2017-11-24 09:14:25
    Oculus: VR Flourishes Despite Predictions of its Death..read more
    Posted in Business on 2017-11-22 23:55:15
    How to Use Technology to Help You Become Debt-Free..read more
    Posted in Medicine on 2017-11-22 23:49:31
    Patients On Medical Cannabis More Likely To Quit Opioids,.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Martian landscapes formed from sand 'levitating' on a little.....read more
    Posted by AlexMuller
    Scientists detect comets outside our solar system..read more
    Posted by AlexMuller
    Advanced artificial limbs mapped in the brain..read more
    Posted by AlexMuller
    Bacteria have a sense of touch..read more
    Posted by AlexMuller
    Recurrent brain cancer: New hope with phase 1 clinical trial.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me