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Scientists trigger self-destruct switch in lung cancer cells

RATE THIS! +35
Posted in Medicine on 1st Nov, 2014 08:45 PM by AlexMuller

Cancer Research UK scientists have found a drug combination that can trigger the self-destruct process in lung cancer cells, paving the way for new treatments, according to research that will be presented at the National Cancer Research Institute (NCRI) Cancer Conference (link is external) in Liverpool next week.

 
When healthy cells are no longer useful they initiate a chain of events culminating in self destruction. But cancer cells swerve away from this suicide path and become immortal. This means that cells grow out of control, causing tumours to form.
 
The Cancer Research UK team, based at the UCL Cancer Institute (link is external), has successfully fixed this fault in lung cancer cells, reprogramming the cells to self-destruct. Using lung cancer cells and mice the scientists showed that the combination of two drugs, called TRAIL and a CDK9 inhibitor, altered the molecular switches in the cell suicide process, forcing the cancer cells to self-destruct.
 
Lead researcher, Cancer Research UK scientist Professor Henning Walczak from the UCL Cancer Institute, said: “Igniting the fuse that causes lung cancer cells to self destruct could pave the way to a completely new treatment approach, and leave healthy cells unharmed.

Tags: cancerlung cancercellstumorCancer Research UK

Read original article » Back to category

Comments

Author: Guest
Posted: 2014-11-02
+2
This is great! Lung cancer is in particular difficult and very little progress has been made during last 10 years to increase survival time, compared to other cancers.
1 Replies
Author: Guest
Posted: 2014-11-02
+1
Yes, there’s an urgent need to save more lives from lung cancer. These findings could one day lead to effective new treatments to help lung cancer patients and potentially those with other cancer types too Reply
Reply
Author: Guest
Posted: 2014-11-02
+2
I hope that the next step will see how this approach works in other cancer types, and could ultimately lead to testing this technique in trials to see if it can help patients-critical step
1 Replies
Author: Guest
Posted: 2014-11-02
+0
Yes, clinical trials are the key. Many findings based on cells in culture or animal models ultimately do not work for humans Reply
Reply
Author: Guest
Posted: 2016-05-06
+0
Great inhsgit! That's the answer we've been looking for. Reply


 

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