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Obesity is Inflammatory Disease, Rat Study Shows

RATE THIS! +41
Posted in Medicine on 9th Dec, 2013 12:25 AM by AlexMuller

“This important new finding links obesity and high fat, high sugar diets with changes in immune cells and inflammatory status, highlighting an emerging realization that obesity is an inflammatory disease,” Dr Fairlie said.

 
“Drugs designed to block certain inflammatory proteins, as in this report, may be able to prevent and treat obesity, which in turn is a major risk factor for type 2 diabetes, heart disease, stroke, kidney failure, limb amputation, and cancers.”
 
To make the discovery, the team discovered the first potent, selective and orally bioavailable small molecule antagonists of PAR2 and characterized their functional responses in inflammatory cellular and animal models.
 
They found that PAR2 expression is increased in vivo in adipose tissue from obese humans and rats, stimulated in vitro in human macrophages by the dietary fatty acid palmitic acid, and inhibited in vivo and in vitro by a PAR2 antagonist. This antagonist was then used as a tool to dissect roles for PAR2 activation in mediating metabolic dysfunction in human monocyte-derived macrophages (HMDM), human and rodent adipocytes, and diet-induced obesity in rats.
 
Oral treatment of diet-induced obese rats attenuated PAR2 signaling in adipose tissue and inhibited adipose inflammation, insulin resistance, diet-induced obesity and cardiovascular abnormalities.
 
This is the first report that a PAR2 antagonist improves obesity, glucose homeostasis and obesity-associated chronic inflammation in vivo.

Tags: obesityfatinflammationhealthfoodinflammatory disease

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Comments

Author: Guest
Posted: 2013-12-09
+2
This is an important but not entirely surprising finding. Obesity is causing complex changes at the level of an entire organism and immune system is involved
3 Replies
Author: Guest
Posted: 2013-12-09
+1
It is so surprising how quickly proportion of overweight people increased during the past 20 years, humans evolved to be on the move with the food limits. Our body metabolism can not change so quickly
1 Replies
Author: Guest
Posted: 2013-12-09
+0
This is the key. The relative abundance of food is a recent development in our evolution Reply
Reply
Author: Guest
Posted: 2013-12-09
+0
Our lifestyle is one major cause of health problems and educating people to change and prevent this continue is priority Reply
Reply
Author: Guest
Posted: 2013-12-09
+1
It is amazing that they already have a potential drug in place and hopefully could soon move towards clinical trials
2 Replies
Author: Guest
Posted: 2013-12-09
+0
It seems that PAR2 antagonism can be an effective intervention for treating metabolic dysfunction and obesity.
1 Replies
Author: Guest
Posted: 2013-12-09
+0
It has been commented that drugs designed to block certain inflammatory proteins, as in this report, may be able to prevent and treat obesity, which in turn is a major risk factor for type 2 diabetes, heart disease, stroke, kidney failure, limb amputation, and cancers Reply
Reply
Reply
Author: Guest
Posted: 2013-12-09
+1
It is important to be very careful when making conclusion about links between body weight and disease - this study is indeed taking care Reply
Author: Guest
Posted: 2013-12-09
+0
More and more research is showing that being overweight should itself diagnosis for illness or indicator of great possibility of one Reply


 

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