Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.

 

Thomas Edison

Molecule developed that helps target T-cells to fight brain cancer

RATE THIS! +2
Posted in Medicine on 8th Sep, 2018 10:15 AM by Alex Muller

T-Cell immunotherapy is a multi-billion dollar success. Companies are genetically engineering an individual’s own immune cells to attack cancer in the blood or lymph system. Chimeric antigen receptor T-cell therapy, or CAR-T therapy has seen huge acquisitions and investments.

 

Gilead Sciences paid $11.9 billion for Kite Pharma, which received FDA approval for its own CAR-T therapy, Yescarta. Celgene paid $9 billion to acquire Juno Therapeutics which is also a leader in CAR-T therapy. Venture capitalists are investing hundreds of millions of dollars into biotech firms with next-generation CAR-T technology.

 

T-Cells to fight brain cancer

 

Successful T cell immunotherapy for brain cancer requires that the T cells can access tumor tissues, but this has been difficult to achieve. Researchers show that, in contrast to inflammatory brain diseases such as multiple sclerosis, where endothelial cells upregulate ICAM1 and VCAM1 to guide the extravasation of pro-inflammatory cells, cancer endothelium downregulates these molecules to evade immune recognition.

 

They found that cancer endothelium upregulates activated leukocyte cell adhesion molecule (ALCAM), which allowed them to overcome this immune-evasion mechanism by creating an ALCAM-restricted homing system (HS).

 

We re-engineered the natural ligand of ALCAM, CD6, in a manner that triggers initial anchorage of T cells to ALCAM and conditionally mediates a secondary wave of adhesion by sensitizing T cells to low-level ICAM1 on the cancer endothelium, thereby creating the adhesion forces necessary to capture T cells from the bloodstream.

 

Cytotoxic HS T cells robustly infiltrated brain cancers after intravenous injection and exhibited potent antitumour activity. They have therefore developed a molecule that targets the delivery of T cells to brain cancer.


Tags: brainneurosciencehealthmedicineresearch

Read original article » Back to category

Comments



 

Recent headlines

  • Posted in Science on 2018-11-18 20:04:45
    Rocket Lab launched seven small satellites..read more
    Posted in Hardware on 2018-11-18 19:58:28
    SpaceX will be going all in to launch unmanned BFR to.....read more
    Posted in Medicine on 2018-11-17 12:31:22
    Anti-aging compounds targeting Alzheimer’s move closer.....read more
    Posted in Hardware on 2018-11-13 05:19:55
    NASA certifies SpaceX's Falcon 9 for its most expensive.....read more
    Posted in Software on 2018-11-09 03:19:01
    OpenAI launches reinforcement learning training..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Even light drinking increases risk of death..read more
    Posted by AlexMuller
    Researchers have discovered how to slow aging..read more
    Posted by AlexMuller
    Human retinas grown in a dish explain how color vision develops..read more
    Posted by AlexMuller
    The smartphone app that can tell you’re depressed before you.....read more
    Posted by AlexMuller
    Neural networks don’t understand what optical illusions are..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me