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How a Concussion Can Lead to Depression Years Later

RATE THIS! +17
Posted in Medicine on 10th Dec, 2013 10:17 PM by AlexMuller

A head injury can lead immune-system brain cells to go on “high alert” and overreact to later immune challenges by becoming excessively inflammatory – a condition linked with depressive complications, a new animal study suggests.

 
The findings could help explain some of the midlife mental-health issues suffered by individuals who experience multiple concussions as young adults, researchers say. And these depressive symptoms are likely inflammation-related, which means they may not respond to common antidepressants.
 
An added complication is that aging already increases brain inflammation. So on top of normal aging concerns, people who have had a traumatic brain injury (TBI) experience added inflammation caused by magnified immune responses to so-called “secondary challenges,” such as a second head injury, infections or other stressors.
 
In mice, these high-alert cells in the brain – called microglia – had an exaggerated response to an immune challenge one month after a moderate brain injury. This increased brain inflammation corresponded with the development of depressive behaviors that were not observed in uninjured mice.
 
“If we had waited three, six or nine months, the symptoms probably would have gotten even worse,” said lead author Jonathan Godbout, associate professor of neuroscience at The Ohio State University and a researcher in the Institute for Behavioral Medicine Research.

Tags: headinjuryhealthbrainconcussiondepressionmental illnessimmune systemneuroscience

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Comments

Author: Guest
Posted: 2013-12-11
+2
Connection between immune disorders, inflammation, and mental illness has been documented before. This is another good evidence that should help further understanding and hopefully treatments
5 Replies
Author: Guest
Posted: 2013-12-11
+0
But it’s important to keep in mind that both infections and mood disorders are very common, making it difficult to work out what could be causing what Reply
Author: Guest
Posted: 2013-12-11
+1
However, it just could be that immune disorders are difficult to cope with. Would you not get depressed if you have problems like this? Reply
Author: Guest
Posted: 2013-12-11
+0
Indeed, a link between infection and depression and mood disorders remains intriguing Reply
Reply
Author: Guest
Posted: 2013-12-11
+1
This adds to previous research that shows that people who suffer multiple concussions have a higher risk of clinical depression. Reply
Author: Guest
Posted: 2013-12-11
+1
Anybody who receives a blow to the head, as in a car accident or fall, may sustain a concussion. But athletes in contact sports such as football or hockey are more likely than the average person to experience multiple concussions. This study is particularly relevant for them. Reply
Author: Guest
Posted: 2016-12-26
+0
Finding this post has anewsred my prayers Reply


 

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