Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.

 

Thomas Edison

Glowing chemical 'could aid brain cancer surgery'

RATE THIS! +7
Posted in Medicine on 6th Nov, 2018 01:18 AM by Alex Muller

A chemical that makes brain tumours glow pink could help surgeons to remove the cancer safely, a trial suggests. Scientists gave people with suspected glioma a drink containing 5-ALA, a substance known to accumulate in fast-growing cancer cells. The pink glow the chemical causes was found in people with the most aggressive cancers.

 

Researchers hope it will make it easier for surgeons to distinguish between cancer cells and healthy brain tissue.

 

Treatment for glioma, the most common form of brain cancer and the one that killed ex-Labour cabinet minister Dame Tessa Jowell, usually involves surgery to remove as much of the cancer as possible, and the prognosis for patients is often poor.

 

For this new trial, 99 patients with suspected high-grade (fast-growing) gliomas were given a drink containing 5-ALA before surgery.

 

Research has previously shown that 5-ALA ends up in fast-growing cancer cells, because they lack an enzyme needed to break down the chemical.

 

Surgeons used microscopes to help them look for fluorescent tissue while removing tumours from the patients' brains.

 

During their operations, surgeons reported seeing fluorescence in 85 patients.

 

Of these, 81 were confirmed by pathologists to have high-grade disease, one was found to have low-grade disease and three could not be assessed.

 

In the 14 patients in whom surgeons did not see any fluorescence, seven tumours were found to be low-grade gliomas while the other seven could not be assessed.

 

Study author Dr Kathreena Kurian, associate professor in brain tumour research at the University of Bristol, said: "There's an urgent need to have something while the patient is on the table, while the neurosurgeon is operating, which will guide them to find the worst bits.

 

"The beauty of 5-ALA is that they can see where high-grade glioma is, while they're operating."

 

The researchers caution that the study looked at patients who were already suspected to have high-grade tumours, and a larger study in which more patients have low-grade disease would provide more information on the use of this technique.

 

Other types of markers may need to be tested for detecting low-grade glioma cells, they say.

 

Next steps could include testing the 5-ALA in children with brain tumours, or to help surgeons distinguish between tumour tissue and scar tissue in adult patients, whose brain cancers have recurred following treatment.

 

Dr Paul Brennan, from Cancer Research UK, said: "Highlighting the more aggressive tumour cells in real-time could help doctors achieve the delicate balance between removing as much of the tumour as possible while preserving surrounding healthy tissue.

 

"The fluorescent marker may also ease the burden of follow-up treatment, as cancer cells left behind after surgery require additional radiotherapy or chemotherapy."

 

The National Institute for Health and Clinical Excellence approved the use of 5-ALA for patients with brain tumours, prior to surgery, earlier this year.

 

The research is being presented at the 2018 NCRI Cancer Conference in Glasgow from 4 to 6 November.


Tags: healthmedicinecancerresearchbiotech

Read original article » Back to category

Comments



 

Recent headlines

  • Posted in Hardware on 2018-11-13 05:19:55
    NASA certifies SpaceX's Falcon 9 for its most expensive.....read more
    Posted in Software on 2018-11-09 03:19:01
    OpenAI launches reinforcement learning training..read more
    Posted in Science on 2018-11-08 03:58:12
    Plan to find and explore Ocean Worlds and search for life..read more
    Posted in Medicine on 2018-11-06 01:18:21
    Glowing chemical 'could aid brain cancer surgery'..read more
    Posted in Business on 2018-11-06 01:11:11
    Space Force will be more about putting up new space.....read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Even light drinking increases risk of death..read more
    Posted by AlexMuller
    Researchers have discovered how to slow aging..read more
    Posted by AlexMuller
    Human retinas grown in a dish explain how color vision develops..read more
    Posted by AlexMuller
    The smartphone app that can tell you’re depressed before you.....read more
    Posted by AlexMuller
    Neural networks don’t understand what optical illusions are..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me