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First use of retrograde gene therapy on a human heart

RATE THIS! +29
Posted in Medicine on 3rd Dec, 2013 10:03 PM by AlexMuller

A new procedure designed to deliver stem cells to the heart to repair damaged muscle and arteries in the most minimally invasive way possible has been performed for the first time.

 
Patel started investigating cell and gene-based therapies for the treatment of heart disease 12 years ago, but only recently received FDA approval to try the therapy on Lively, who was the first of several patients anxious to receive the treatment.
 
More than 6 million people are currently living with heart failure. As the condition progresses, patients’ options are usually limited to a heart transplant or assist devices, such as an artificial heart. Patel wanted to find a way to intervene in the progression of heart failure before a patient advanced to the point of needing a heart transplant or device.
 
A minimally invasive surgical procedure
 
Patel and his team came up with the idea of retrograde heart therapy, a concept that has been discussed for 50 years. The first successful procedure was performed Nov. 7 on actor Ernie Lively, whose credentials that include a long list of TV and film appearances, including Passenger 57 and The Sisterhood of the Traveling Pants.
 
“It’s incredible. Imagine having a heart procedure that can potentially regenerate or rejuvenate your heart muscle — and it’s done as an outpatient procedure,” said Patel.
 
Patel uses a minimally invasive technique where he goes backwards through a patient’s main cardiac vein, or coronary sinus, and inserts a catheter. He then inflates a balloon in order to block blood flow out of the heart so that a very high dose of gene therapy can be infused directly into the heart.
 
The unique gene therapy doesn’t involve viruses (a rarity for gene therapy, Patel notes) and is pure human DNA infused into patients.  The DNA, called SDF-1, is a naturally occurring substance in the body that becomes a homing signal for a patient’s body to use its own stem cells to go to the site of an injury.

Tags: retrograde gene therapygeneticsDNAstem cellsheartsurgeryhealthregenerative medicine

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Comments

Author: Guest
Posted: 2013-12-04
+2
Heart procedures are becoming more and sophisticated and that in fact means simpler for patients - it is great that this one has FDA approval Reply
Author: Guest
Posted: 2013-12-04
+3
Great progress. More than 6 million people are currently living with heart failure. As the condition progresses, patients' options are usually limited to a heart transplant or assist devices, such as an artificial heart. Reply
Author: Guest
Posted: 2013-12-04
+0
Great use of SDF-1 DNA to act as a as "homing beacons." When the genes are put into patients with heart failure, they marinate the entire heart and act like a look out. Reply
Author: Guest
Posted: 2013-12-04
+2
Patel is already training other physicians around the U.S. to model what he accomplished first this month. Reply


 

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