Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.

 

Thomas Edison

First steps have been taken for vaccines in pill form

RATE THIS! +34
Posted in Medicine on 14th Mar, 2018 06:52 AM by Alex Muller

Scientists have taken steps towards creating new vaccine treatments in pill form. The team has made a prototype oral flu vaccine, which unlike standard inoculations does not need to be stored in a freezer. They hope it could pave the way for needle-free inoculations for lots of diseases that would be easier to use in developing countries.

 

However, they said more work was needed before it could be tested in people.

 

Traditional biological vaccines work by introducing a safe form of a virus or bacteria – or a harmless part of it, such as a peptide – in order to provoke an immune response in the body. This allows the body to recognise an illness, such as flu, and deal with it more effectively should it ever encounter it for real. But the difficulty with these biological vaccines is that they need to be frozen or refrigerated throughout transport to keep them stable, making them costly and difficult to deliver in countries without a reliable electrical supply.

 

For this new influenza-A vaccine, scientists at Cardiff University created man-made peptides that mimic those in real viruses. Unlike the biological peptides, these “mirror image” molecules cannot be digested, opening up the possibility for them to be administered in pill form. The study, published in the Journal of Clinical Investigation, found the prototype triggered a strong immune system response in human cells when tested in a culture dish.

 

And it was as effective as the standard biological influenza peptide when tested in mice. It was also shown to generate cells that kill the influenza virus when it was given orally to the mice. Prof Andrew Sewell, from Cardiff University’s school of medicine, who led the study, said: “There are many benefits to oral vaccines.

 

“Not only would they be great news for people who have a fear of needles but they can also be much easier to store and transport, making them far more suitable for use in remote locations where current vaccine delivery systems can be problematic.”

 

However, researchers acknowledged that much more research was needed to develop these synthetic vaccinations for the entire population and for other diseases.UK scientists have taken the first steps towards creating new vaccine treatments in pill form.

 

The Cardiff team has made a prototype oral flu vaccine, which unlike standard inoculations does not need to be stored in a fridge or freezer. They hope it could pave the way for needle-free inoculations for lots of different diseases that would be easier to use in developing countries. However, they said more work was needed before it could be tested in people.

 

Traditional biological vaccines work by introducing a safe form of a virus or bacteria – or a harmless part of it, such as a peptide – in order to provoke an immune response in the body. This allows the body to recognise an illness, such as flu, and deal with it more effectively should it ever encounter it for real. But the difficulty with these biological vaccines is that they need to be frozen or refrigerated throughout transport to keep them stable, making them costly and difficult to deliver in countries without a reliable electrical supply.

 

For this new influenza-A vaccine, scientists at Cardiff University created man-made peptides that mimic those in real viruses. Unlike the biological peptides, these “mirror image” molecules cannot be digested, opening up the possibility for them to be administered in pill form. The study, published in the Journal of Clinical Investigation, found the prototype triggered a strong immune system response in human cells when tested in a culture dish.

 

And it was as effective as the standard biological influenza peptide when tested in mice. It was also shown to generate cells that kill the influenza virus when it was given orally to the mice. Prof Andrew Sewell, from Cardiff University’s school of medicine, who led the study, said: “There are many benefits to oral vaccines.

 

“Not only would they be great news for people who have a fear of needles but they can also be much easier to store and transport, making them far more suitable for use in remote locations where current vaccine delivery systems can be problematic.”

 

However, researchers acknowledged that much more research was needed to develop these synthetic vaccinations for the entire population and for other diseases. 


Tags: healthmedicinepillresearchvaccine

Read original article » Back to category

Comments



 

Recent headlines

  • Posted in Science on 2018-12-09 23:56:38
    CRISPR Babies: Mankind's Next Giant Leap?..read more
    Posted in Hardware on 2018-12-07 14:22:16
    SpaceX Successfully Launches to Space Station But Rocket.....read more
    Posted in Science on 2018-12-07 14:17:51
    Simulated One Gravity Living on the Moon and Mars With a.....read more
    Posted in Business on 2018-12-07 14:12:33
    Most Valuable Company Title Moved Between Amazon, Apple.....read more
    Posted in Science on 2018-12-04 03:51:30
    SpaceX Lessons Which Massively Speed Improvement of Products..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Even light drinking increases risk of death..read more
    Posted by AlexMuller
    Researchers have discovered how to slow aging..read more
    Posted by AlexMuller
    Human retinas grown in a dish explain how color vision develops..read more
    Posted by AlexMuller
    The smartphone app that can tell you’re depressed before you.....read more
    Posted by AlexMuller
    Neural networks don’t understand what optical illusions are..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me