Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

Just because something doesn’t do what you planned it to do doesn’t mean it’s useless.

 

Thomas Edison

Diabetes drug reverses symptoms Alzheimer's in mice

RATE THIS! +36
Posted in Medicine on 2nd Jan, 2018 06:02 PM by Alex Muller

The connection between diabetes and Alzheimer's disease has been studied for years, with some scientists suggesting the two conditions are different stages of the same disease. Rresearch has now discovered that a drug initially developed for diabetes has "significantly reversed memory loss" in early animal trials.

 
The new research led by Professor Christian Holscher of Lancaster University looked at the neuro-protective effects of a novel diabetes drug called a triple receptor agonist. This drug was initially designed to treat type 2 diabetes by activating GLP-1, GIP and Glucagon growth factor receptors in the brain.
 
The study used transgenic mice engineered to express the same mutated genes that cause Alzheimer's in humans. After exposure to the triple receptor agonist the mice displayed significant improvements in a maze-based memory test and reductions in chronic inflammation, oxidative stress and amyloid plaques in the brain.
 
Past research has already confirmed that single agonist drugs developed for diabetes display neuroprotective effects in animal models, but this is the first time that a triple receptor drug has been studied for these effects. Professor Holscher sees clear promise in these results, and while more research needs to be done, this does point to a potential new treatment for those suffering from Alzheimer's disease.
 
"Here we show that a novel triple receptor drug shows promise as a potential treatment for Alzheimer's but further dose-response tests and direct comparisons with other drugs have to be conducted in order to evaluate if this new drugs is superior to previous ones," says Holscher.
 
Perhaps an even more compelling outcome of this study is that it adds to a growing body of evidence that links diabetes to Alzheimer's. Of course, not everyone who develops type 2 diabetes will go on to develop Alzheimer's, but there is a possible causal link between impaired insulin signaling and increased amyloid plaques in the brain.

Tags: healthmedicinediabetesbrainresearch

Read original article » Back to category

Comments

Author: Guest
Posted: 2018-01-03
+1
Indeed, understanding dementia and links with disorders such as type 2 diabetes and inflammation is of great importance for developments of new treatments
1 Replies
Author: Guest
Posted: 2018-01-03
+0
And, as this news article describes, this overlap and link provides the opportunity for repurposing already FDA approved drugs. In this case, patients with Alzheimer's benefit from drugs developed to treat diabetes Reply
Reply


 

Recent headlines

  • Posted in Medicine on 2018-06-22 05:28:13
    New discovery could put the brakes on metastatic cancer..read more
    Posted in Software on 2018-06-21 03:22:47
    IBM Unveils System That 'Debates' With Humans..read more
    Posted in Science on 2018-06-21 03:12:27
    NASA unveils bold new plan to protect Earth from asteroids..read more
    Posted in Science on 2018-06-21 03:03:04
    Machine learning may be a game-changer for climate.....read more
    Posted in Science on 2018-06-20 02:26:18
    Pushing the limit: could cyanobacteria terraform Mars?..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    In five years quantum computing will be mainstream..read more
    Posted by AlexMuller
    Google partners with Johnson and Johnson to make lower cost.....read more
    Posted by AlexMuller
    Electron holography microscope with spatial resolution down to.....read more
    Posted by AlexMuller
    Lower cost advanced Nuclear power could dominate future US energy..read more
    Posted by AlexMuller
    Why Hasn’t AI Mastered Language Translation?..read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me