Brain region implicated in emotional disturbance in dementia patients

A study by researchers at Neuroscience Research Australia (NeuRA) is the first to demonstrate that patients with frontotemporal dementia (FTD) lose the emotional content/colour of their memories.
 
 These findings explain why FTD patients may not vividly remember an emotionally charged event like a wedding or funeral.
 
The research team discovered that a region of the brain, called the orbitofrontal cortex, plays a key role in linking emotion and memories.
 
“This step forward in the mapping of the brain will improve how we diagnose different types of dementia,” says the study’s lead author, Associate Professor Olivier Piguet.
 
The fact that we vividly remember events infused with emotion – like birthday parties – is well established. Patients with frontotemporal dementia (FTD) – a degenerative condition that affects the frontal and temporal lobes of the brain – show profound difficulty understanding and expressing emotion. Yet the extent to which such deficits weaken emotional enhancement of memory remains unknown.
 
To find out, the NeuRA team showed patients images that prompt an emotional reaction in healthy people. Healthy control subjects and patients with Alzheimer’s disease remembered more emotional than neutral images. The FTD patients, however, did not.
 
Professor Piguet says, “Up until now, we knew that emotional memories were supported by the amygdala, a brain region also involved with emotion regulation. This study is the first to demonstrate the involvement of the orbitofrontal cortex in this process. This is an important development in how we understand the relations between emotions and memory and the disturbance of the emotional system in this type of dementia.”