Social Media Sidebar

Announcement

Please sign up, comment on articles and bring your friends!

Current poll

PlanetTech is asking:

What do you think about our new web site?

Love it, indeed
Really good solution
Same as old one
The old one was better
This is a new option

Quote of the day

When seen through the lens of technology, few resources are truly scarce; they’re mainly inaccessible. 

 

Peter Diamandis

Blood plasma from young donors improves functional ability for Alzheimers

RATE THIS! +35
Posted in Medicine on 6th Nov, 2017 05:08 PM by Alex Muller

Stanford investigators have reported success in an early-phase clinical trial examining the safety, tolerability and feasibility of administering infusions of blood plasma from young donors to participants with mild to moderate Alzheimer’s disease.

 

There were also some signs suggesting improvements in participants’ conditions.

 
Above – Sharon Sha presented findings Nov. 4 from a small clinical trial that found administering blood plasma from young donors to people with mild to moderate Alzheimer’s disease was safe. Paul Sakuma
 
Finding of safety wasn’t surprising, given that blood-plasma infusions have long been in widespread use for other indications and are considered extremely safe. More surprising, she said, were hints of recipients’ improvement on tests of functional ability: the capacity to perform basic tasks essential to independent daily life, such as remembering to take medications and being able to pay bills and prepare one’s own meals.
 
The PLASMA trial was designed to test a hypothesis advanced by Tony Wyss-Coray, PhD, Stanford professor of neurology and neurological sciences and a senior research career scientist at the Veterans Affairs Palo Alto Health Care System, whose research has shown that factors in the blood of young mice can rejuvenate the brain tissue and improve cognitive performance in old mice.
 
Sha, the clinical core co-leader of the Stanford Alzheimer’s Disease Research Center and the medical director of the Stanford Neuroscience Clinical Trials Group, cautioned that these assessments were based on caregiver reports and that the number of participants in the study — 18 — was small. Further studies on larger numbers of participants will be necessary before conclusions about efficacy can be reached, Sha said.
 
Improvements in functional ability
 
An analysis of assessments once all participants had been treated showed no significant changes in participants’ mood or their performance on tests of cognition involving tasks such as memorizing lists or recalling recent events, Sha said. These kinds of changes are typically observed only in clinical trials whose durations exceed one year, she added, so the absence of an effect here wasn’t particularly unanticipated.
 
But on two of three different assessments of functional ability, participants showed statistically significant improvement — this, despite the trial’s small size.
 
“That was surprising, to me,” said Sha. “The trial wasn’t powered to show efficacy.”
 
At first, the investigators suspected that the report of improvements in functional ability might have been driven by the second group of participants, who along with their caregivers and the investigators themselves knew they were getting plasma; this could perhaps predispose caregivers to optimistic reporting. But examination of the data indicated that, to the contrary, it was the first group of participants — who had no idea whether they were getting plasma or placebo — who showed the most improvement in functional ability after receiving plasma infusions.

Tags: healthmedicinebiologyresearchAlzheimer'sneuroscience

Read original article » Back to category

Comments



 

Recent headlines

  • Posted in Science on 2017-11-20 00:42:21
    Small steps forward as UN climate talks end in Bonn..read more
    Posted in Hardware on 2017-11-20 00:37:56
    US gov should support SpaceX and develop moon bases..read more
    Posted in Business on 2017-11-18 21:15:58
    Companies are realising that renewable energy is good for.....read more
    Posted in Hardware on 2017-11-18 21:07:25
    California may reach 50% renewable power goal by 2020; 10.....read more
    Posted in Hardware on 2017-11-17 18:02:34
    Tesla unveils a truck and a roadster..read more
Posted in Business on 2013-10-10 01:33
China is working towards a manned lunar mission in about.....read more
Posted in Business on 2013-10-20 07:17
Spacex says China is their main competitor for commercial.....read more
Posted in Software on 2013-10-20 06:43
Pirate Bay Browser Clocks 1,000,000 Downloads..read more
Posted in Medicine on 2013-10-10 02:10
Google reportedly investing hundreds of millions into new.....read more
Posted in Medicine on 2013-10-14 03:13
Endothelial Cells Can Repair and Regenerate Organs,.....read more
Posted in Science on 01.01.2010
Spacex says China is their main competitor for commercial.....read more
Posted in Science on 01.01.2010
Staring at Your Phone Could Be Making You Short Sighted..read more
Posted in Science on 01.01.2010
Oculus Rift virtual reality headset coming to mobile, but.....read more
Posted in Science on 01.01.2010
China is working towards a manned lunar mission in about.....read more
Posted in Science on 01.01.2010
Delivering drugs via nanoparticles to target mitochondria..read more

Recent Blog Posts

  • Posted by AlexMuller
    Martian landscapes formed from sand 'levitating' on a little.....read more
    Posted by AlexMuller
    Scientists detect comets outside our solar system..read more
    Posted by AlexMuller
    Advanced artificial limbs mapped in the brain..read more
    Posted by AlexMuller
    Bacteria have a sense of touch..read more
    Posted by AlexMuller
    Recurrent brain cancer: New hope with phase 1 clinical trial.....read more

Login to your Account

Login to your PlanetTech Account here

Username:
Password:
Remember me
or

Create a New Account

You just need username and password

The following errors occured:
Username:
Email:
Password:
Verify password:
Remember me